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Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors.
Meharena, Hiruy S; Marco, Asaf; Dileep, Vishnu; Lockshin, Elana R; Akatsu, Grace Y; Mullahoo, James; Watson, L Ashley; Ko, Tak; Guerin, Lindsey N; Abdurrob, Fatema; Rengarajan, Shruthi; Papanastasiou, Malvina; Jaffe, Jacob D; Tsai, Li-Huei.
Affiliation
  • Meharena HS; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: hiruym@mit.edu.
  • Marco A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Dileep V; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Lockshin ER; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Akatsu GY; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Mullahoo J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Watson LA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Ko T; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Guerin LN; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Abdurrob F; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Rengarajan S; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Papanastasiou M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Jaffe JD; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: l
Cell Stem Cell ; 29(1): 116-130.e7, 2022 01 06.
Article in En | MEDLINE | ID: mdl-34995493
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down Syndrome / Induced Pluripotent Stem Cells / Neural Stem Cells Limits: Humans Language: En Journal: Cell Stem Cell Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down Syndrome / Induced Pluripotent Stem Cells / Neural Stem Cells Limits: Humans Language: En Journal: Cell Stem Cell Year: 2022 Document type: Article