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Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1α-mediated transcriptional regulation of their transporters.
Sabui, Subrata; Ramamoorthy, Kalidas; Romero, Jose M; Simoes, Rita D; Fleckenstein, James M; Said, Hamid M.
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  • Sabui S; Department of Physiology and Biophysics, UCI, Irvine, California, USA; Department of Research, VA Medical Center, Long Beach, California, USA.
  • Ramamoorthy K; Department of Physiology and Biophysics, UCI, Irvine, California, USA.
  • Romero JM; Department of Research, VA Medical Center, Long Beach, California, USA; Department of Medicine, UCI, Irvine, California, USA.
  • Simoes RD; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.
  • Fleckenstein JM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA; Department Medicine Service, Veterans Affairs Medical Center, St Louis, Missouri, USA.
  • Said HM; Department of Physiology and Biophysics, UCI, Irvine, California, USA; Department of Research, VA Medical Center, Long Beach, California, USA; Department of Medicine, UCI, Irvine, California, USA. Electronic address: hmsaid@uci.edu.
J Biol Chem ; 298(2): 101562, 2022 02.
Article in En | MEDLINE | ID: mdl-34998824
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiamine / Hypoxia-Inducible Factor 1, alpha Subunit / Microbiota Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiamine / Hypoxia-Inducible Factor 1, alpha Subunit / Microbiota Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2022 Document type: Article