Metformin Repurposing for Parkinson Disease Therapy: Opportunities and Challenges.

Agostini, Francesco; Masato, Anna; Bubacco, Luigi; Bisaglia, Marco

Agostini, Francesco; Masato, Anna; Bubacco, Luigi; Bisaglia, Marco.

Affiliation

Agostini F; Department of Biology, University of Padova, 35121 Padova, Italy.
Masato A; Department of Biology, University of Padova, 35121 Padova, Italy.
Bubacco L; Department of Biology, University of Padova, 35121 Padova, Italy.
Bisaglia M; Center Study for Neurodegeneration (CESNE), University of Padova, 35121 Padova, Italy.

Int J Mol Sci ; 23(1)2021 Dec 30.

Article in En | MEDLINE | ID: mdl-35008822

Subject(s)

Drug Repositioning; Metformin/therapeutic use; Parkinson Disease/drug therapy; Animals; Autophagy/drug effects; Biological Availability; Humans; Metformin/administration & dosage; Metformin/adverse effects; Metformin/pharmacology; Neuroprotective Agents/administration & dosage; Neuroprotective Agents/pharmacology; Neuroprotective Agents/therapeutic use

Key words

AMPK; Parkinson disease; bioavailability; epidemiology; metformin; neuroprotection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Drug Repositioning / Metformin Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article

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