The Anti-Inflammatory Effect of the ß1-Adrenergic Receptor Antagonist Metoprolol on High Glucose Treated Human Microvascular Retinal Endothelial Cells.

Giurdanella, Giovanni; Longo, Anna; Distefano, Alfio; Olivieri, Melania; Cristaldi, Martina; Cosentino, Alessia; Agafonova, Aleksandra; Caporarello, Nunzia; Lupo, Gabriella; Anfuso, Carmelina Daniela

Giurdanella, Giovanni; Longo, Anna; Distefano, Alfio; Olivieri, Melania; Cristaldi, Martina; Cosentino, Alessia; Agafonova, Aleksandra; Caporarello, Nunzia; Lupo, Gabriella; Anfuso, Carmelina Daniela.

Affiliation

Giurdanella G; Biochemistry Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Longo A; Biochemistry Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Distefano A; Biochemistry Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Olivieri M; U.O. Clinical Pathology, Department of Hematology, AUSL Romagna, 47522 Cesena, Italy.
Cristaldi M; Fidia Farmaceutici S.p.A., 95123 Catania, Italy.
Cosentino A; Biochemistry Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Agafonova A; Biochemistry Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Caporarello N; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Lupo G; Biochemistry Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Anfuso CD; Biochemistry Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.

Cells ; 11(1)2021 12 24.

Article in En | MEDLINE | ID: mdl-35011613

Subject(s)

Adrenergic beta-1 Receptor Antagonists/pharmacology; Anti-Inflammatory Agents/pharmacology; Endothelial Cells/pathology; Glucose/toxicity; Metoprolol/pharmacology; Microvessels/pathology; Retina/pathology; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cell Proliferation/drug effects; Cyclooxygenase 2/metabolism; Down-Regulation/drug effects; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Epinephrine/pharmacology; Heme Oxygenase-1/metabolism; Humans; Interleukin-1beta/metabolism; Kelch-Like ECH-Associated Protein 1/metabolism; MAP Kinase Signaling System/drug effects; NF-E2-Related Factor 2/metabolism; Neovascularization, Physiologic/drug effects; Phospholipases A2, Cytosolic/metabolism; Phosphorylation/drug effects; Protein Transport/drug effects; Reactive Oxygen Species/metabolism; Tumor Necrosis Factor-alpha/metabolism; Vascular Endothelial Growth Factor A/metabolism

Key words

Kelch-like ECH-associated protein 1 (Keap1); Phospholipase A2 (PLA2); diabetic retinopathy (DR); human retinal endothelial cells (HREC); metoprolol; nuclear factor erythroid-2-related factor 2 (Nrf2); ß-Adrenergic Receptor (ß-AR)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retina / Endothelial Cells / Microvessels / Adrenergic beta-1 Receptor Antagonists / Glucose / Metoprolol / Anti-Inflammatory Agents Limits: Humans Language: En Journal: Cells Year: 2021 Document type: Article

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