Liraglutide, a glucagon-like peptide-1 receptor agonist, induces ADAM10-dependent ectodomain shedding of RAGE via AMPK activation in human aortic endothelial cells.

Baek, Chung Hee; Kim, Hyosang; Moon, Soo Young; Yang, Won Seok

Baek, Chung Hee; Kim, Hyosang; Moon, Soo Young; Yang, Won Seok.

Affiliation

Baek CH; Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kim H; Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Moon SY; Asan Institute for Life Sciences, Seoul, Republic of Korea.
Yang WS; Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: wsyang@amc.seoul.kr.

Life Sci ; 292: 120331, 2022 Mar 01.

Article in En | MEDLINE | ID: mdl-35041837

Subject(s)

Aorta; Epithelial Cells; Glucagon-Like Peptide-1 Receptor/antagonists & inhibitors; Glycation End Products, Advanced/metabolism; Liraglutide/pharmacology; Aorta/drug effects; Aorta/pathology; Cell Line; Epithelial Cells/drug effects; Epithelial Cells/pathology; Humans

Key words

A disintegrin and metalloprotease 10; AMP-activated protein kinase; Ectodomain shedding; Liraglutide; Receptor for advanced glycation end products

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Glycation End Products, Advanced / Epithelial Cells / Liraglutide / Glucagon-Like Peptide-1 Receptor Limits: Humans Language: En Journal: Life Sci Year: 2022 Document type: Article

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