Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification.

Choezom, Dolma; Gross, Julia Christina

Choezom, Dolma; Gross, Julia Christina.

Affiliation

Choezom D; Developmental Biochemistry, University Medical Center Goettingen, 37077 Goettingen, Germany.
Gross JC; Developmental Biochemistry, University Medical Center Goettingen, 37077 Goettingen, Germany.

J Cell Sci ; 135(5)2022 03 01.

Article in En | MEDLINE | ID: mdl-35050379

Subject(s)

Exosomes; Vacuolar Proton-Translocating ATPases; Endosomal Sorting Complexes Required for Transport/metabolism; Endosomes/metabolism; Exosomes/metabolism; Humans; Hydrogen-Ion Concentration; Multivesicular Bodies/metabolism; Protein Transport; Sphingomyelin Phosphodiesterase/genetics; Sphingomyelin Phosphodiesterase/metabolism; Vacuolar Proton-Translocating ATPases/genetics; Vacuolar Proton-Translocating ATPases/metabolism

Key words

Endosomal cargo sorting; Endosomal maturation; Intraluminal vesicles; Secretory multivesicular bodies; Small extracellular vesicles

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vacuolar Proton-Translocating ATPases / Exosomes Limits: Humans Language: En Journal: J Cell Sci Year: 2022 Document type: Article

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