Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease.

Mi, Jing; He, Ying; Yang, Jing; Zhou, Yi; Zhu, Gaofeng; Wu, Anguo; Liu, Wenmin; Sang, Zhipei

Mi, Jing; He, Ying; Yang, Jing; Zhou, Yi; Zhu, Gaofeng; Wu, Anguo; Liu, Wenmin; Sang, Zhipei.

Affiliation

Mi J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
He Y; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
Yang J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
Zhou Y; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
Zhu G; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550004, China.
Wu A; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Southwest Medical University, Luzhou 646000, China. Electronic address: wuanguo@swmu.edu.cn.
Liu W; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China. Electronic address: liuwm1969@163.com.
Sang Z; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China. Electronic address: sangzhipei@126.com.

Bioorg Med Chem Lett ; 60: 128574, 2022 03 15.

Article in En | MEDLINE | ID: mdl-35065231

Subject(s)

Alzheimer Disease/drug therapy; Antioxidants/pharmacology; Carbamates/pharmacology; Cholinesterase Inhibitors/pharmacology; Flavanones/pharmacology; Neuroprotective Agents/pharmacology; Acetylcholinesterase/metabolism; Alzheimer Disease/metabolism; Amyloid beta-Peptides/antagonists & inhibitors; Amyloid beta-Peptides/metabolism; Animals; Antioxidants/chemical synthesis; Antioxidants/chemistry; Butyrylcholinesterase/metabolism; Carbamates/chemical synthesis; Carbamates/chemistry; Cell Line; Cell Survival/drug effects; Cholinesterase Inhibitors/chemical synthesis; Cholinesterase Inhibitors/chemistry; Copper/pharmacology; Dose-Response Relationship, Drug; Drug Development; Flavanones/chemical synthesis; Flavanones/chemistry; Humans; Molecular Structure; Neuroprotective Agents/chemical synthesis; Neuroprotective Agents/chemistry; Peptide Fragments/antagonists & inhibitors; Peptide Fragments/metabolism; Protein Aggregates/drug effects; Rats; Structure-Activity Relationship

Key words

Alzheimer's disease; Blood-brain barrier penetration; Multi-function agents; Naringenin-O-carbamate derivatives

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbamates / Cholinesterase Inhibitors / Neuroprotective Agents / Flavanones / Alzheimer Disease / Antioxidants Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Year: 2022 Document type: Article

Fulltext

XML

PubMed Links

Search on Google