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Establishment and characterization of human induced pluripotent stem cell line from a Parkinson's disease patient harboring VPS13A gene mutation.
Lu, Xianjie; Wang, Wei; Liu, Yanming; Song, Na; Li, Mengpeng; Mu, Xin; Zhang, Nan; Chen, Qingfa; Jiang, Licheng; Kong, Xianglin; Sun, Peng; Tong, Jiabei; Zhang, Yunping; Li, Jingtao; Ma, Shengjun; Han, Fabin.
Affiliation
  • Lu X; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Wang W; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Liu Y; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Song N; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Li M; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Mu X; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Zhang N; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Chen Q; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Jiang L; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China.
  • Kong X; The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.
  • Sun P; The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.
  • Tong J; Shandong Meijia Therapeutics, Jinan 252013, Shandong, China.
  • Zhang Y; Department of Dermatology, Liaocheng People's Hospital, Liaocheng 252000, Shandong, China.
  • Li J; Department of Thoracic Surgery, Liaocheng People's Hospital, Liaocheng 252000, Shandong, China.
  • Ma S; Department of Cardiac Surgery, Liaocheng People's Hospital, Liaocheng 252000, Shandong, China. Electronic address: msj6336@126.com.
  • Han F; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng 252000, Shandong, China; The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese M
Stem Cell Res ; 60: 102685, 2022 04.
Article in En | MEDLINE | ID: mdl-35093716
ABSTRACT
Mutations in VPS13 gene have been recently reported as a genetic cause of Parkinson's disease (PD). In this study, we isolated the skin fibroblasts from a PD patient harboring VPS13A gene mutation (c. 4282_4289delinsA) and reprogrammed the fibroblasts to a novel patient-specific induced pluripotent stem cell (iPSC) line LCPHi002-A using transgene-free episomal plasmids to express OCT3/4, SOX2, KLF4, L-MYC, and LIN28. The LCPHi002-A line showed the normal karyotype, expression of pluripotency markers, and had multi-lineage differentiation capacity in vivo. This iPSC line of LCPHi002-A could be used for studying pathogenic mechanisms of PD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Induced Pluripotent Stem Cells Limits: Humans Language: En Journal: Stem Cell Res Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Induced Pluripotent Stem Cells Limits: Humans Language: En Journal: Stem Cell Res Year: 2022 Document type: Article