Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.

Xi, Meiyang; Feng, Chengjie; Du, Kui; Lv, Weiping; Du, Chenxi; Shen, Runpu; Sun, Haopeng

Xi, Meiyang; Feng, Chengjie; Du, Kui; Lv, Weiping; Du, Chenxi; Shen, Runpu; Sun, Haopeng.

Affiliation

Xi M; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, China.
Feng C; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, China; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing 312000, China.
Du K; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, China.
Lv W; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Du C; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Shen R; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, China; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing 312000, China. Electronic address: srunpu@usx.edu.cn.
Sun H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: sunhaopeng@163.com.

Bioorg Med Chem Lett ; 61: 128602, 2022 04 01.

Article in En | MEDLINE | ID: mdl-35124202

Subject(s)

Alzheimer Disease/drug therapy; Butyrylcholinesterase/metabolism; Cholinesterase Inhibitors/pharmacology; Drug Design; Acetylcholinesterase/metabolism; Alzheimer Disease/metabolism; Cell Line; Cell Survival/drug effects; Cholinesterase Inhibitors/chemical synthesis; Cholinesterase Inhibitors/chemistry; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship

Key words

AD; Docking; MD simulation; Selective BuChE inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butyrylcholinesterase / Drug Design / Cholinesterase Inhibitors / Alzheimer Disease Limits: Humans Language: En Journal: Bioorg Med Chem Lett Year: 2022 Document type: Article

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