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Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice.
Deng, Li-Dong; Qi, Lin; Suo, Qian; Wu, Sheng-Ju; Mamtilahun, Muyassar; Shi, Ru-Bing; Liu, Ze; Sun, Jun-Feng; Tang, Yao-Hui; Zhang, Zhi-Jun; Yang, Guo-Yuan; Wang, Ji-Xian.
Affiliation
  • Deng LD; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Qi L; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Suo Q; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Wu SJ; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Mamtilahun M; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Shi RB; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Liu Z; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Sun JF; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Tang YH; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Zhang ZJ; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Yang GY; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University; Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wang JX; Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, and Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Neural Regen Res ; 17(9): 2058-2063, 2022 Sep.
Article in En | MEDLINE | ID: mdl-35142697
ABSTRACT
Blood-brain barrier (BBB) disruption underlies the vasogenic edema and neuronal cell death induced by acute ischemic stroke. Reducing this disruption has therapeutic potential. Transcranial focused ultrasound stimulation has shown neuromodulatory and neuroprotective effects in various brain diseases including ischemic stroke. Ultrasound stimulation can reduce inflammation and promote angiogenesis and neural circuit remodeling. However, its effect on the BBB in the acute phase of ischemic stroke is unknown. In this study of mice subjected to middle cerebral artery occlusion for 90 minutes, low-intensity low-frequency (0.5 MHz) transcranial focused ultrasound stimulation was applied 2, 4, and 8 hours after occlusion. Ultrasound stimulation reduced edema volume, improved neurobehavioral outcomes, improved BBB integrity (enhanced tight junction protein ZO-1 expression and reduced IgG leakage), and reduced secretion of the inflammatory factors tumor necrosis factor-α and activation of matrix metalloproteinase-9 in the ischemic brain. Our results show that low-intensity ultrasound stimulation attenuated BBB disruption and edema formation, which suggests it may have therapeutic use in ischemic brain disease as a protector of BBB integrity.
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Language: En Journal: Neural Regen Res Year: 2022 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Language: En Journal: Neural Regen Res Year: 2022 Document type: Article