Half of germline pathogenic and likely pathogenic variants found on panel tests do not fulfil NHS testing criteria.

Andoni, Tala; Wiggins, Jennifer; Robinson, Rachel; Charlton, Ruth; Sandberg, Michael; Eeles, Rosalind

Andoni, Tala; Wiggins, Jennifer; Robinson, Rachel; Charlton, Ruth; Sandberg, Michael; Eeles, Rosalind.

Affiliation

Andoni T; The Institute of Cancer Research, London, UK. talaandoni@gmail.com.
Wiggins J; Royal Marsden Hospital, London, UK.
Robinson R; Leeds Genetics Laboratory, St James's University Hospital, Leeds, UK.
Charlton R; Leeds Genetics Laboratory, St James's University Hospital, Leeds, UK.
Sandberg M; 90 Sloane Street, London, UK.
Eeles R; The Institute of Cancer Research, London, UK.

Sci Rep ; 12(1): 2507, 2022 02 21.

Article in En | MEDLINE | ID: mdl-35190596

Subject(s)

Biomarkers, Tumor/genetics; Genetic Counseling/standards; Genetic Testing/standards; Neoplasms/epidemiology; State Medicine/standards; Adolescent; Adult; Aged; Aged, 80 and over; England/epidemiology; Female; Genetic Counseling/statistics & numerical data; Genetic Predisposition to Disease; Genetic Testing/statistics & numerical data; Germ-Line Mutation; Humans; Incidence; Male; Middle Aged; Neoplasms/diagnosis; Neoplasms/genetics; Retrospective Studies; Risk Assessment/standards; Risk Assessment/statistics & numerical data; Young Adult

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: State Medicine / Biomarkers, Tumor / Genetic Testing / Genetic Counseling / Neoplasms Type of study: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Sci Rep Year: 2022 Document type: Article

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