[CARL-Controlled reperfusion of the whole body]. / CARL ­ kontrollierte Reperfusion des ganzen Körpers: Von der kardiopulmonalen Reanimation zur zielgerichteten eCPR.

ABSTRACT

BACKGROUND: The incidence and mortality of acute cardiovascular arrest have been consistently high for decades. OBJECTIVE: How to improve the currently unsatisfactory outcome after resuscitation regarding survival and neurological, especially cerebral, sequelae? MATERIAL AND METHODS: Development of a therapeutic approach to curtail ischemia/reperfusion injury in an animal model. Development of a device system optimized for resuscitation that can be used to implement controlled reperfusion of the whole body outside the hospital. RESULTS: Establishment of CARL treatment in the clinic and in the treatment of OHCA patients. Transfer of the CARL treatment and system in a clinical observational study. First case reports in which patients survived OHCA without brain damage even after ischemia times up to 2 h. CONCLUSION: CARL treatment is potentially suitable to treat patients suffering from cardiovascular arrest refractory to treatment even for prolonged periods.