Effectiveness of crizotinib versus entrectinib in ROS1-positive non-small-cell lung cancer using clinical and real-world data.
Future Oncol
; 18(17): 2063-2074, 2022 Jun.
Article
in En
| MEDLINE
| ID: mdl-35232230
ABSTRACT
Aims:
To compare clinical trial results for crizotinib and entrectinib in ROS1-positive non-small-cell lung cancer and compare clinical trial data and real-world outcomes for crizotinib. Patients &methods:
We analyzed four phase I-II studies using a simulated treatment comparison (STC). A STC of clinical trial versus real-world evidence compared crizotinib clinical data to real-world outcomes.Results:
Adjusted STC found nonsignificant trends favoring crizotinib over entrectinib objective response rate, risk ratio = 1.04 (95% CI 0.85-1.28); median duration of response, mean difference = 16.11 months (95% CI -1.57- 33.69); median progression-free survival, mean difference = 3.99 months (95% CI -6.27-14.25); 12-month overall survival, risk ratio = 1.01 (95% CI 0.90-1.12). Nonsignificant differences were observed between the trial end point values and the real-world evidence for crizotinib.Conclusions:
Crizotinib and entrectinib have comparable efficacy in ROS1-positive non-small-cell lung cancer.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Non-Small-Cell Lung
/
Protein Kinase Inhibitors
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Lung Neoplasms
Limits:
Humans
Language:
En
Journal:
Future Oncol
Year:
2022
Document type:
Article