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2'-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity.
Honcharenko, Dmytro; Rocha, Cristina S J; Lundin, Karin E; Maity, Jyotirmoy; Milton, Stefan; Tedebark, Ulf; Murtola, Merita; Honcharenko, Malgorzata; Slaitas, Andis; Smith, C I Edvard; Zain, Rula; Strömberg, Roger.
Affiliation
  • Honcharenko D; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
  • Rocha CSJ; Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.
  • Lundin KE; Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.
  • Maity J; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
  • Milton S; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
  • Tedebark U; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
  • Murtola M; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
  • Honcharenko M; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
  • Slaitas A; Syntagon Baltic, Babites novads, Latvia.
  • Smith CIE; Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.
  • Zain R; Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.
  • Strömberg R; Department of Clinical Genetics, Center for Rare Diseases, Karolinska University Hospital, Stockholm, Sweden.
Nucleic Acid Ther ; 32(3): 221-233, 2022 06.
Article in En | MEDLINE | ID: mdl-35238623
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides, Antisense / Phosphorothioate Oligonucleotides Language: En Journal: Nucleic Acid Ther Year: 2022 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides, Antisense / Phosphorothioate Oligonucleotides Language: En Journal: Nucleic Acid Ther Year: 2022 Document type: Article