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Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures.
Jurickova, Ingrid; Bonkowski, Erin; Angerman, Elizabeth; Novak, Elizabeth; Huron, Alex; Akers, Grayce; Iwasawa, Kentaro; Braun, Tzipi; Hadar, Rotem; Hooker, Maria; Han, Sarah; Cutler, David J; Okou, David T; Kugathasan, Subra; Jegga, Anil; Wells, James; Takebe, Takanori; Mollen, Kevin P; Haberman, Yael; Denson, Lee A.
Affiliation
  • Jurickova I; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Bonkowski E; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Angerman E; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Novak E; Division of General and Thoracic Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Huron A; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Akers G; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Iwasawa K; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Braun T; Division of Biomedical Informatics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Hadar R; Department of Pediatrics, Sheba Medical Center, Tel-Aviv University, Tel-HaShomer, Israel.
  • Hooker M; Department of Pediatrics, Sheba Medical Center, Tel-Aviv University, Tel-HaShomer, Israel.
  • Han S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Cutler DJ; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Okou DT; Department of Human Genetics, Emory University, Atlanta, GA, USA.
  • Kugathasan S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University, Atlanta, GA, USA.
  • Jegga A; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University, Atlanta, GA, USA.
  • Wells J; Division of Biomedical Informatics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Takebe T; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Mollen KP; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Haberman Y; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Denson LA; Institute of Research, Tokyo Medical and Dental University, Japan.
Inflamm Bowel Dis ; 28(7): 988-1003, 2022 07 01.
Article in En | MEDLINE | ID: mdl-35259271
A subset of pediatric Crohn's disease patients develop intestinal strictures requiring surgery. The microbial metabolite butyrate and eicosatetraynoic acid regulate pathways implicated in stricture formation in a human intestinal organoid model system, which may be used to test new therapies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease Limits: Humans Language: En Journal: Inflamm Bowel Dis Year: 2022 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease Limits: Humans Language: En Journal: Inflamm Bowel Dis Year: 2022 Document type: Article