Neuronal SNARE complex assembly guided by Munc18-1 and Munc13-1.
FEBS Open Bio
; 12(11): 1939-1957, 2022 11.
Article
in En
| MEDLINE
| ID: mdl-35278279
ABSTRACT
Neurotransmitter release by Ca2+ -triggered synaptic vesicle exocytosis is essential for information transmission in the nervous system. The soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) syntaxin-1, SNAP-25, and synaptobrevin-2 form the SNARE complex to bring synaptic vesicles and the plasma membranes together and to catalyze membrane fusion. Munc18-1 and Munc13-1 regulate synaptic vesicle priming via orchestrating neuronal SNARE complex assembly. In this review, we summarize recent advances toward the functions and molecular mechanisms of Munc18-1 and Munc13-1 in guiding neuronal SNARE complex assembly, and discuss the functional similarities and differences between Munc18-1 and Munc13-1 in neurons and their homologs in other intracellular membrane trafficking systems.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Munc18 Proteins
/
Membrane Fusion
Language:
En
Journal:
FEBS Open Bio
Year:
2022
Document type:
Article