Safety of glucose-6 phosphate dehydrogenase deficient donors in living right lobe liver donation.
Clin Transplant
; 36(6): e14627, 2022 06.
Article
in En
| MEDLINE
| ID: mdl-35279872
ABSTRACT
BACKGROUND:
The literature lacks data on World Health Organization (WHO) class II and III deficient liver donors who underwent right hepatectomy during living donor liver transplantation (LDLT).METHODS:
In this prospective cohort study, we compared the perioperative outcomes of 15 glucose-6 phosphate dehydrogenase (G6PD) deficient living liver donors with a matched cohort of 39 nondeficient living liver donors undergoing right lobe donation.RESULTS:
Out of 15 G6PD deficient donors, four (26.67%) donors had class II, and 11 (73.34%) had class III G6PD deficiency. The mean postoperative trough hemoglobin level was significantly lower in the deficient group than the nondeficient group (9.38 ± 1.59 g/dL vs. 10.27 ± .91 g/dL, p = .046). The mean peak indirect bilirubin level was significantly higher in the deficient group than the nondeficient group (2.22 ± 1.38 mg/dL vs. 1.40 ± .89 mg/dL, p = .047), and a similar trend was observed in total serum bilirubin (3.99 ± 2.57 mg/dL vs. 2.99 ± 1.46 mg/dL, p = .038). Biochemical evidence of hemolysis was found only in three (20%) deficient donors, but none of them needed a blood transfusion. No mortality was observed in either group. All other parameters, including demographics, operative parameters, graft characteristics, and hospital stay were comparable between both groups (p > .05).CONCLUSION:
G6PD deficiency with WHO class II and above should not be considered a contraindication for right lobe donation.Key words
Full text:
1
Collection:
01-internacional
Health context:
2_ODS3
Database:
MEDLINE
Main subject:
Liver Transplantation
/
Glucosephosphate Dehydrogenase Deficiency
Type of study:
Observational_studies
Limits:
Humans
Language:
En
Journal:
Clin Transplant
Year:
2022
Document type:
Article