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A Study on Lower Limb Asymmetries in Parkinson's Disease during Gait Assessed through Kinematic-Derived Parameters.
Arippa, Federico; Leban, Bruno; Monticone, Marco; Cossu, Giovanni; Casula, Carlo; Pau, Massimiliano.
Affiliation
  • Arippa F; Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, 09123 Cagliari, Italy.
  • Leban B; Neurorehabilitation Unit, Department of Neuroscience and Rehabilitation, ARNAS "G. Brotzu", 09134 Cagliari, Italy.
  • Monticone M; Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, 09123 Cagliari, Italy.
  • Cossu G; Neurorehabilitation Unit, Department of Neuroscience and Rehabilitation, ARNAS "G. Brotzu", 09134 Cagliari, Italy.
  • Casula C; Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.
  • Pau M; Neurophysiology and Movement Disorders Unit, Department of Neurology, ARNAS "G. Brotzu", 09134 Cagliari, Italy.
Bioengineering (Basel) ; 9(3)2022 Mar 16.
Article in En | MEDLINE | ID: mdl-35324809
Unilaterality of motor symptoms is a distinctive feature of Parkinson's Disease (PD) and represents an important co-factor involved in motor deficits and limitations of functional abilities including postural instability and asymmetrical gait. In recent times, an increasing number of studies focused on the characterization of such alterations, which have been associated with increased metabolic cost and risk of falls and may severely compromise their quality of life. Although a large number of studies investigated the gait alterations in people with PD (pwPD), few focused on kinematic parameters and even less investigated interlimb asymmetry under a kinematic point of view. This retrospective study aimed to characterize such aspects in a cohort of 61 pwPD (aged 68.9 ± 9.3 years) and 47 unaffected individuals age- and sex-matched (66.0 ± 8.3 years), by means of computerized 3D gait analysis performed using an optical motion-capture system. The angular trends at hip, knee and ankle joints of pwPD during the gait cycle were extracted and compared with those of unaffected individuals on a point-by-point basis. Interlimb asymmetry was assessed using angle-angle diagrams (cyclograms); in particular, we analyzed area, orientation, trend symmetry and range offset. The results showed that pwPD are characterized by a modified gait pattern particularly at the terminal stance/early swing phase of the gait cycle. Significant alterations of interlimb coordination were detected at the ankle joint (cyclogram orientation and trend symmetry) and at the hip joint (range offset). Such findings might be useful in clinical routine to characterize asymmetry during gait and thus support physicians in the early diagnosis and in the evaluation of the disease progression.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Risk_factors_studies / Screening_studies Aspects: Patient_preference Language: En Journal: Bioengineering (Basel) Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Risk_factors_studies / Screening_studies Aspects: Patient_preference Language: En Journal: Bioengineering (Basel) Year: 2022 Document type: Article