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Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects.
Zuo, Zhicheng; Babu, Kesavan; Ganguly, Chhandosee; Zolekar, Ashwini; Newsom, Sydney; Rajan, Rakhi; Wang, Yu-Chieh; Liu, Jin.
Affiliation
  • Zuo Z; College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, People's Republic of China; Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Babu K; Shanghai Frontiers Science Research Center for Druggability of Cardiovascular noncoding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai, People's Republic of China; Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Ganguly C; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas, USA; Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Zolekar A; Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, USA; and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Newsom S; Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, USA; and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Rajan R; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas, USA; Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Wang YC; Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, USA; and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Liu J; Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, USA; and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
CRISPR J ; 5(2): 329-340, 2022 04.
Article in En | MEDLINE | ID: mdl-35438515
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CRISPR-Cas Systems / Gene Editing Limits: Humans Language: En Journal: CRISPR J Year: 2022 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CRISPR-Cas Systems / Gene Editing Limits: Humans Language: En Journal: CRISPR J Year: 2022 Document type: Article