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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis.
Oberkersch, Roxana E; Pontarin, Giovanna; Astone, Matteo; Spizzotin, Marianna; Arslanbaeva, Liaisan; Tosi, Giovanni; Panieri, Emiliano; Ricciardi, Sara; Allega, Maria Francesca; Brossa, Alessia; Grumati, Paolo; Bussolati, Benedetta; Biffo, Stefano; Tardito, Saverio; Santoro, Massimo M.
Affiliation
  • Oberkersch RE; Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy.
  • Pontarin G; Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy.
  • Astone M; Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy.
  • Spizzotin M; Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy.
  • Arslanbaeva L; Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy.
  • Tosi G; Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy.
  • Panieri E; Molecular Biotechnology Center, University of Turin, Turin, Italy.
  • Ricciardi S; National Institute of Molecular Genetics (INGM) and Department of Biosciences, University of Milan, Milan, Italy.
  • Allega MF; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G611BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G611QH, UK.
  • Brossa A; Molecular Biotechnology Center, University of Turin, Turin, Italy.
  • Grumati P; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
  • Bussolati B; Molecular Biotechnology Center, University of Turin, Turin, Italy.
  • Biffo S; National Institute of Molecular Genetics (INGM) and Department of Biosciences, University of Milan, Milan, Italy.
  • Tardito S; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G611BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G611QH, UK.
  • Santoro MM; Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy. Electronic address: massimo.santoro@unipd.it.
Dev Cell ; 57(10): 1241-1256.e8, 2022 05 23.
Article in En | MEDLINE | ID: mdl-35580611
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspartic Acid / Neovascularization, Physiologic / Endothelial Cells / Mechanistic Target of Rapamycin Complex 1 / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Dev Cell Year: 2022 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspartic Acid / Neovascularization, Physiologic / Endothelial Cells / Mechanistic Target of Rapamycin Complex 1 / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Dev Cell Year: 2022 Document type: Article