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Two New Xanthones from the Twigs of Calophyllum membranaceum and Their Anti-Inflammatory Activities in HESC Cells.
Li, Si-Yuan; Mi, Ya-Hui; Shen, Wei; Hu, Xiao-Long; Zhang, Jing; Nan, Fang; Song, Zhe; Zhang, Xiao-Qi; Ye, Wen-Cai; Wang, Hao.
Affiliation
  • Li SY; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China.
  • Mi YH; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China.
  • Shen W; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China.
  • Hu XL; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China.
  • Zhang J; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China.
  • Nan F; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China.
  • Song Z; Instrumental Analysis Center, China Pharmaceutical University, Nanjing, 210009, P. R. China.
  • Zhang XQ; Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, P. R. China.
  • Ye WC; Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, P. R. China.
  • Wang H; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China.
Chem Biodivers ; 19(7): e202200355, 2022 Jul.
Article in En | MEDLINE | ID: mdl-35621358
ABSTRACT
Two new xanthones, calmemxanthone A (1) and calmemxanthone B (2), along with eleven known compounds were isolated from the dried twigs of Calophyllum membranaceum Gardn. et Champ. The structures of compounds 1 and 2 were established by analysis of spectra and mass spectrometry data. The absolute configuration of compound 1 was confirmed by electronic circular dichroism (ECD) spectral analysis. The anti-inflammation action of these compounds were evaluated on lipopolysaccharide (LPS)-induced inflammatory damage to human endometrial stromal cells (HESCs), and the structure-activities of 1-13 were also discussed. Compound 10 presented the anti-inflammation action with an IC50 value of 20.3 µM, that might be relevant to the regulation of NF-κB signaling pathway via the suppression of TRIF, IKKα, and IκBα.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calophyllum / Xanthones / Human Embryonic Stem Cells Limits: Humans Language: En Journal: Chem Biodivers Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calophyllum / Xanthones / Human Embryonic Stem Cells Limits: Humans Language: En Journal: Chem Biodivers Year: 2022 Document type: Article