A Human Ex Vivo Skin Model to Study Candida auris Biofilms.
Methods Mol Biol
; 2517: 259-267, 2022.
Article
in En
| MEDLINE
| ID: mdl-35674961
ABSTRACT
Candida auris can persist for long periods on hospital surfaces and on the skin. C. auris has the ability to form drug-resistant biofilms, which can substantially impact on patient outcome. In comparison to Candida albicans, C. auris has a lower capacity to form biofilms in in vitro models and a higher capacity when tested on animal skin models. Intraspecies variation is shown to exist, with some clinical isolates having greater biofilm capabilities than others. There is a need for models that closely mimic the real niches where infection occurs on human patients. This protocol describes, in detail, a human skin model to study C. auris biofilm formation using catheterized and non-catheterized skin.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Candida
/
Candidiasis
Type of study:
Guideline
Limits:
Animals
/
Humans
Language:
En
Journal:
Methods Mol Biol
Year:
2022
Document type:
Article