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Two new isoflavones from the roots of Sophora tonkinensis.
Chen, Dao-Jun; Yuan, Shuang; Zhang, Peng; An, Qiao; Zou, Ji-Bin; Yuan, Chun-Mao; Zhao, Li-Hua; Hu, Zhan-Xing; Hao, Xiao-Jiang.
Affiliation
  • Chen DJ; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
  • Yuan S; Guizhou Bailing Enterprise Group Pharmaceutical Co., Ltd, Anshun 561000, China.
  • Zhang P; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
  • An Q; Guizhou Bailing Enterprise Group Pharmaceutical Co., Ltd, Anshun 561000, China.
  • Zou JB; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
  • Yuan CM; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
  • Zhao LH; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
  • Hu ZX; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
  • Hao XJ; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
J Asian Nat Prod Res ; 25(2): 163-170, 2023 Feb.
Article in En | MEDLINE | ID: mdl-35675145
Two new isoflavones (1 and 2), as well as eight known ones were isolated from the roots of Sophora tonkinensis Gagnep. Compound 1 represents an unprecedented polymerization pattern constructed by isoflavone and cytisine. Their structures were elucidated by comprehensive spectroscopic data analysis, combined with ECD calculations. Compound 1 displayed significant anti-tobacco mosaic virus (TMV) activity compared with the positive control ningnanmycin. Moreover, compound 6 exhibited potent α-glucosidase inhibitory activity with IC50 value of 47.4 mg/L.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sophora / Alkaloids / Isoflavones Language: En Journal: J Asian Nat Prod Res Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sophora / Alkaloids / Isoflavones Language: En Journal: J Asian Nat Prod Res Year: 2023 Document type: Article