Your browser doesn't support javascript.
loading
Augmentation of the RNA m6A reader signature is associated with poor survival by enhancing cell proliferation and EMT across cancer types.
Oh, Jaeik; Hwa, Chanwoong; Jang, Dongjun; Shin, Seungjae; Lee, Soo-Jin; Kim, Jiwon; Lee, Sang Eun; Jung, Hae Rim; Oh, Yumi; Jang, Giyong; Kwon, Obin; An, Joon-Yong; Cho, Sung-Yup.
Affiliation
  • Oh J; Department of Translational Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.
  • Hwa C; Department of Internal Medicine, Seoul National University Hospital, Seoul, 03080, Korea.
  • Jang D; School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, 02841, Korea.
  • Shin S; BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul, 02841, Korea.
  • Lee SJ; Department of Integrated Biomedical and Life Science, Korea University, Seoul, 02841, Korea.
  • Kim J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
  • Lee SE; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
  • Jung HR; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
  • Oh Y; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
  • Jang G; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
  • Kwon O; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
  • An JY; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
  • Cho SY; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
Exp Mol Med ; 54(7): 906-921, 2022 07.
Article in En | MEDLINE | ID: mdl-35794212
ABSTRACT
N6-Methyladenosine (m6A) RNA modification plays a critical role in the posttranscriptional regulation of gene expression. Alterations in cellular m6A levels and m6A-related genes have been reported in many cancers, but whether they play oncogenic or tumor-suppressive roles is inconsistent across cancer types. We investigated common features of alterations in m6A modification and m6A-related genes during carcinogenesis by analyzing transcriptome data of 11 solid tumors from The Cancer Genome Atlas database and our in-house gastric cancer cohort. We calculated m6A writer (W), eraser (E), and reader (R) signatures based on corresponding gene expression. Alterations in the W and E signatures varied according to the cancer type, with a strong positive correlation between the W and E signatures in all types. When the patients were divided according to m6A levels estimated by the ratio of the W and E signatures, the prognostic effect of m6A was inconsistent according to the cancer type. The R and especially the R2 signatures (based on the expression of IGF2BPs) were upregulated in all cancers. Patients with a high R2 signature exhibited poor prognosis across types, which was attributed to enrichment of cell cycle- and epithelial-mesenchymal transition-related pathways. Our study demonstrates common features of m6A alterations across cancer types and suggests that targeting m6A R proteins is a promising strategy for cancer treatment.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Adenosine Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Exp Mol Med Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Adenosine Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Exp Mol Med Year: 2022 Document type: Article