The effect of exogenous GM1 ganglioside on kindled-amygdaloid seizures.
Neuropharmacology
; 26(2-3): 261-4, 1987.
Article
in En
| MEDLINE
| ID: mdl-3587534
ABSTRACT
The effects of 12 daily doses of 30 mg/kg GM1 ganglioside i.p. on the acquisition of kindled-amygdaloid seizures in the rat was studied. No modification in the rate of kindling or the expression of the elicited seizures was noted during the acquisition phase. Further studies with additional fully amygdaloid kindled rats failed to show significant modification of suprathreshold or threshold elicited seizures after single 30-60 mg/kg i.p. doses of GM1 ganglioside. Despite previous studies which have shown antibodies to GM1 ganglioside to be convulsive, no anticonvulsant activity was demonstrated in this study with exogenous GM1 ganglioside using a battery of kindled-amygdaloid seizure tests in the rat.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seizures
/
Gangliosides
/
Amygdala
/
Kindling, Neurologic
Limits:
Animals
Language:
En
Journal:
Neuropharmacology
Year:
1987
Document type:
Article