[Heritability and genetic correlation of body mass index and coronary heart disease in Chinese adult twins].
Zhonghua Yu Fang Yi Xue Za Zhi
; 56(7): 940-946, 2022 Jul 06.
Article
in Zh
| MEDLINE
| ID: mdl-35899346
ABSTRACT
Objective:
To examine the heritability of body mass index (BMI) and coronary heart disease (CHD), and to explore whether genetic factors can explain their correlation.Methods:
Participants were from 11 provinces/municipalities reqistered in the Chinese National Twin Registry (CNTR) from 2010 to 2018. Participants data were collected from face-to-face questionnaire survey. Bivariate structure equation model was used to estimate the heritability and the genetic correlation of BMI and CHD.Results:
A total of 20 340 pairs of same-sex twins aged ≥25 years were included in this study. After adjusting for age and gender, the heritability of BMI and CHD was 0.52 (95%CI 0.49-0.55) and 0.76 (95%CI 0.69-0.81), respectively. Further, a genetic correlation was identified between BMI and CHD (rA=0.10, 95%CI0.02-0.17).Conclusion:
In Chinese adult twin population, BMI and CHD are affected by genetic factors, and their correlation can be attributed to the common genetic basis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Twins
/
Coronary Disease
Type of study:
Prognostic_studies
/
Qualitative_research
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Zhonghua Yu Fang Yi Xue Za Zhi
Year:
2022
Document type:
Article