Your browser doesn't support javascript.
loading
[Heritability and genetic correlation of body mass index and coronary heart disease in Chinese adult twins].
Xi, Y E; Gao, W J; Hong, X M; Lyu, J; Yu, C Q; Wang, S F; Huang, T; Sun, D J Y; Liao, C X; Pang, Y J; Pang, Z C; Yu, M; Wang, H; Wu, X P; Dong, Z; Wu, F; Jiang, G H; Wang, X J; Liu, Y; Deng, J; Lu, L; Cao, W H; Li, Liming.
Affiliation
  • Xi YE; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Gao WJ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Hong XM; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Lyu J; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Yu CQ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Wang SF; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Huang T; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Sun DJY; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Liao CX; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Pang YJ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Pang ZC; Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
  • Yu M; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
  • Wang H; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
  • Wu XP; Sichuan Center for Disease Control and Prevention, Chengdu 610041, China.
  • Dong Z; Beijing Center for Disease Prevention and Control, Beijing 100013, China.
  • Wu F; Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
  • Jiang GH; Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
  • Wang XJ; Qinghai Center for Disease Prevention and Control, Xining 810007, China.
  • Liu Y; Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150030, China.
  • Deng J; Handan Center for Disease Control and Prevention, Handan 056001, China.
  • Lu L; Yunnan Center for Disease Control and Prevention, Kunming 650034, China.
  • Cao WH; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Zhonghua Yu Fang Yi Xue Za Zhi ; 56(7): 940-946, 2022 Jul 06.
Article in Zh | MEDLINE | ID: mdl-35899346
ABSTRACT

Objective:

To examine the heritability of body mass index (BMI) and coronary heart disease (CHD), and to explore whether genetic factors can explain their correlation.

Methods:

Participants were from 11 provinces/municipalities reqistered in the Chinese National Twin Registry (CNTR) from 2010 to 2018. Participants data were collected from face-to-face questionnaire survey. Bivariate structure equation model was used to estimate the heritability and the genetic correlation of BMI and CHD.

Results:

A total of 20 340 pairs of same-sex twins aged ≥25 years were included in this study. After adjusting for age and gender, the heritability of BMI and CHD was 0.52 (95%CI 0.49-0.55) and 0.76 (95%CI 0.69-0.81), respectively. Further, a genetic correlation was identified between BMI and CHD (rA=0.10, 95%CI0.02-0.17).

Conclusion:

In Chinese adult twin population, BMI and CHD are affected by genetic factors, and their correlation can be attributed to the common genetic basis.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Twins / Coronary Disease Type of study: Prognostic_studies / Qualitative_research Limits: Adult / Humans Country/Region as subject: Asia Language: Zh Journal: Zhonghua Yu Fang Yi Xue Za Zhi Year: 2022 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Twins / Coronary Disease Type of study: Prognostic_studies / Qualitative_research Limits: Adult / Humans Country/Region as subject: Asia Language: Zh Journal: Zhonghua Yu Fang Yi Xue Za Zhi Year: 2022 Document type: Article