Head-tail-head neural wiring underlies gut fat storage in Caenorhabditis elegans temperature acclimation.
Proc Natl Acad Sci U S A
; 119(32): e2203121119, 2022 08 09.
Article
in En
| MEDLINE
| ID: mdl-35914124
ABSTRACT
Animals maintain the ability to survive and reproduce by acclimating to environmental temperatures. We showed here that Caenorhabditis elegans exhibited temperature acclimation plasticity, which was regulated by a head-tail-head neural circuitry coupled with gut fat storage. After experiencing cold, C. elegans individuals memorized the experience and were prepared against subsequent cold stimuli. The cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) regulated temperature acclimation in the ASJ thermosensory neurons and RMG head interneurons, where it modulated ASJ thermosensitivity in response to past cultivation temperature. The PVQ tail interneurons mediated the communication between ASJ and RMG via glutamatergic signaling. Temperature acclimation occurred via gut fat storage regulation by the triglyceride lipase ATGL-1, which was activated by a neuropeptide, FLP-7, downstream of CREB. Thus, a head-tail-head neural circuit coordinated with gut fat influenced experience-dependent temperature acclimation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tail
/
Adipose Tissue
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Caenorhabditis elegans
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Cold Temperature
/
Digestive System
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Head
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Acclimatization
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Neural Pathways
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2022
Document type:
Article