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Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19.
Demarest, James F; Kienle, Maryline; Boytz, RuthMabel; Ayres, Mary; Kim, Eun Jung; Patten, J J; Chung, Donghoon; Gandhi, Varsha; Davey, Robert A; Sykes, David B; Shohdy, Nadim; Pottage, John C; Kumar, Vikram S.
Affiliation
  • Demarest JF; Clear Creek Bio, Cambridge, MA, USA.
  • Kienle M; Clear Creek Bio, Cambridge, MA, USA.
  • Boytz R; NEIDL, Boston University, Boston, MA, USA.
  • Ayres M; Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX, USA.
  • Kim EJ; University of Louisville, Louisville, KY, USA.
  • Patten JJ; NEIDL, Boston University, Boston, MA, USA.
  • Chung D; University of Louisville, Louisville, KY, USA.
  • Gandhi V; Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX, USA.
  • Davey RA; NEIDL, Boston University, Boston, MA, USA.
  • Sykes DB; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Shohdy N; Clear Creek Bio, Cambridge, MA, USA.
  • Pottage JC; Clear Creek Bio, Cambridge, MA, USA.
  • Kumar VS; Clear Creek Bio, Cambridge, MA, USA. Electronic address: brq@clearcreekbio.com.
Antiviral Res ; 206: 105403, 2022 10.
Article in En | MEDLINE | ID: mdl-36041646
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Viruses / COVID-19 Drug Treatment Limits: Humans Language: En Journal: Antiviral Res Year: 2022 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Viruses / COVID-19 Drug Treatment Limits: Humans Language: En Journal: Antiviral Res Year: 2022 Document type: Article