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Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.
Cronin, Shane J F; Rao, Shuan; Tejada, Miguel A; Turnes, Bruna Lenfers; Licht-Mayer, Simon; Omura, Takao; Brenneis, Christian; Jacobs, Emily; Barrett, Lee; Latremoliere, Alban; Andrews, Nick; Channon, Keith M; Latini, Alexandra; Arvanites, Anthony C; Davidow, Lance S; Costigan, Michael; Rubin, Lee L; Penninger, Josef M; Woolf, Clifford J.
Affiliation
  • Cronin SJF; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Rao S; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  • Tejada MA; Institute of Molecular Biotechnology Austria (IMBA), Dr. Bohrgasse 3, Vienna A-1030, Austria.
  • Turnes BL; Institute of Molecular Biotechnology Austria (IMBA), Dr. Bohrgasse 3, Vienna A-1030, Austria.
  • Licht-Mayer S; Institute of Molecular Biotechnology Austria (IMBA), Dr. Bohrgasse 3, Vienna A-1030, Austria.
  • Omura T; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Brenneis C; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  • Jacobs E; Institute of Molecular Biotechnology Austria (IMBA), Dr. Bohrgasse 3, Vienna A-1030, Austria.
  • Barrett L; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Latremoliere A; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  • Andrews N; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Channon KM; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  • Latini A; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Arvanites AC; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  • Davidow LS; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Costigan M; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  • Rubin LL; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Penninger JM; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  • Woolf CJ; Departments of Neurosurgery and Neuroscience, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Sci Transl Med ; 14(660): eabj1531, 2022 08 31.
Article in En | MEDLINE | ID: mdl-36044597
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lung Neoplasms / Neuralgia Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Year: 2022 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lung Neoplasms / Neuralgia Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Year: 2022 Document type: Article