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Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers.
Xu, Yuqiu; Wei, Zhuang; Feng, Mei; Zhu, Dexiang; Mei, Shenglin; Wu, Zhongen; Feng, Qingyang; Chang, Wenju; Ji, Meiling; Liu, Chenglong; Zhu, Yuanyuan; Shen, Lian; Yang, Fan; Chen, Yijiao; Feng, Yuxiong; Xu, Jianmin; Zhu, Di.
Affiliation
  • Xu Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Wei Z; Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031, China.
  • Feng M; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Zhu D; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Mei S; Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Science and Technology, Tongji University, Shanghai 200433, China.
  • Wu Z; School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 201203, China.
  • Feng Q; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Chang W; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Ji M; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Liu C; School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 201203, China.
  • Zhu Y; School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 201203, China.
  • Shen L; School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 201203, China.
  • Yang F; School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 201203, China.
  • Chen Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Feng Y; Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310058, China.
  • Xu J; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: xujmin@aliyun.com.
  • Zhu D; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. Electronic address: zhudi@fudan.edu.cn.
Cell Rep ; 40(9): 111295, 2022 08 30.
Article in En | MEDLINE | ID: mdl-36044847
ABSTRACT
More than 40% of patients with late-stage colorectal cancer (CRC) develop liver metastasis (LM). Which immune cells play important roles in CRC-LM and contribute to the difference between left-sided CRC (LCC) and right-sided CRC (RCC) remain unclear. By single-cell RNA sequencing (scRNA-seq), we not only find that activated B cells are significantly depleted in CRC with LM, but also find a subtype of B cells developed from activated B cells, namely immature plasma cell population alpha (iMPA), highly correlated with metastasis. Mechanistically, inhibition of the Wnt and transforming growth factor ß (TGF-ß) pathways in cancer cell promotes activated B cell migration via the SDF-1-CXCR4 axis. This study reveals that B cell subpopulations in the tumor immune microenvironment (TIME) play a key role in CRC-LM as well as in LCC and RCC. The preventive effects of modulating B cell subpopulations in CRC may provide a rationale for subsequent drug development and CRC-LM management.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Colorectal Neoplasms / Kidney Neoplasms / Liver Neoplasms Limits: Humans Language: En Journal: Cell Rep Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Colorectal Neoplasms / Kidney Neoplasms / Liver Neoplasms Limits: Humans Language: En Journal: Cell Rep Year: 2022 Document type: Article