Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone Attenuates TNBS-Induced Experimental Colitis.

Szandruk-Bender, Marta; Wiatrak, Benita; Dzimira, Stanislaw; Merwid-Lad, Anna; Szczukowski, Lukasz; Swiatek, Piotr; Szelag, Adam

Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Attenuates TNBS-Induced Experimental Colitis.

Szandruk-Bender, Marta; Wiatrak, Benita; Dzimira, Stanislaw; Merwid-Lad, Anna; Szczukowski, Lukasz; Swiatek, Piotr; Szelag, Adam.

Affiliation

Szandruk-Bender M; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Wiatrak B; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Dzimira S; Department of Pathology, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland.
Merwid-Lad A; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Szczukowski L; Department of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Swiatek P; Department of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Szelag A; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.

Int J Mol Sci ; 23(17)2022 Aug 31.

Article in En | MEDLINE | ID: mdl-36077306

Subject(s)

Colitis; Inflammatory Bowel Diseases; Animals; Colitis/chemically induced; Colitis/drug therapy; Colitis/metabolism; Cytokines/metabolism; Disease Models, Animal; Inflammatory Bowel Diseases/drug therapy; Interleukin-17/metabolism; Interleukin-23/metabolism; Interleukin-6/metabolism; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism; Oxadiazoles; Prostaglandins E/adverse effects; Rats; STAT3 Transcription Factor/metabolism; T-Lymphocytes, Regulatory/metabolism; Th17 Cells/metabolism; Trinitrobenzenesulfonic Acid/adverse effects; Tumor Necrosis Factor-alpha/metabolism

Key words

Foxp3; IL-23; IL-6; RORÎ³t; Th17/Treg axis; experimental colitis; inflammatory bowel disease; inflammatory mediators; pyrrolo[3,4-d]pyridazinone; trinitrobenzenesulfonic acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Colitis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article

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