Insights of Valacyclovir in Treatment of Alzheimer's Disease: Computational Docking Studies and Scopolamine Rat Model.

Patel, Parmi; Faldu, Khushboo; Borisa, Ankit; Bhatt, Hardik; Shah, Jigna

Patel, Parmi; Faldu, Khushboo; Borisa, Ankit; Bhatt, Hardik; Shah, Jigna.

Affiliation

Patel P; Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.
Faldu K; Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.
Borisa A; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.
Bhatt H; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.
Shah J; Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.

Curr Neurovasc Res ; 19(3): 344-357, 2022.

Article in En | MEDLINE | ID: mdl-36089794

Subject(s)

Alzheimer Disease; Prodrugs; Aged; Rats; Humans; Animals; Alzheimer Disease/chemically induced; Alzheimer Disease/drug therapy; Alzheimer Disease/pathology; Amyloid beta-Peptides; Valacyclovir/therapeutic use; Butyrylcholinesterase/therapeutic use; Scopolamine/therapeutic use; Acetylcholinesterase; Donepezil/therapeutic use; Prodrugs/therapeutic use; Acyclovir/therapeutic use; Antiviral Agents/therapeutic use

Key words

Alzheimer's disease; acetylcholinesterase; amyloid-beta 1-42; beta-secretase 1; butyrylcholinesterase; disease-modifying activity; phosphorylated tau; valacyclovir

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Alzheimer Disease Type of study: Prognostic_studies Limits: Aged / Animals / Humans Language: En Journal: Curr Neurovasc Res Year: 2022 Document type: Article

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