Isolated hypoaldosteronism managed by DOCP in a dog with chronic kidney disease and hypercortisolism.
Vet Med Sci
; 8(6): 2292-2296, 2022 11.
Article
in En
| MEDLINE
| ID: mdl-36106511
ABSTRACT
A 13-year-old spayed female Schnauzer dog with chronic kidney disease (CKD; International Renal Interest Society stage 2, non-proteinuric, normotensive), diabetes mellitus, hypercortisolism and myxomatous mitral valve degeneration (American College of Veterinary Internal Medicine stage B2) presented with electrolyte imbalance that had progressed to hyperkalaemia and hyponatremia, with a sodium to potassium (NaK) ratio of 19.6. Cortisol levels after the adrenocorticotropic hormone stimulation test were within the therapeutic range, but aldosterone levels were below the reference range; hence, isolated hypoaldosteronism was diagnosed. After administration of deoxycorticosterone pivalate (DOCP), the electrolyte imbalance improved with a NaK ratio of 27.7. This is the first report of the management of isolated hypoaldosteronism and hypercortisolism using trilostane and DOCP in a dog. This case highlights the importance of recognizing isolated hypoaldosteronism after long-term treatment with trilostane in a canine patient with CKD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hypoaldosteronism
/
Cushing Syndrome
/
Dog Diseases
/
Renal Insufficiency, Chronic
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Vet Med Sci
Year:
2022
Document type:
Article