Translating Animal Models of Ischemic Stroke to the Human Condition.
Transl Stroke Res
; 14(6): 842-853, 2023 12.
Article
in En
| MEDLINE
| ID: mdl-36125734
ABSTRACT
Ischemic stroke is a leading cause of death and disability. However, very few neuroprotective agents have shown promise for treatment of ischemic stroke in clinical trials, despite showing efficacy in many successful preclinical studies. This may be attributed, at least in part, to the incongruency between experimental animal stroke models used in preclinical studies and the manifestation of ischemic stroke in humans. Most often the human population selected for clinical trials are more diverse than the experimental model used in a preclinical study. For successful translation, it is critical to develop clinical trial designs that match the experimental animal model used in the preclinical study. This review aims to provide a comprehensive summary of commonly used animal models with clear correlates between rodent models used to study ischemic stroke and the clinical stroke pathologies with which they most closely align. By improving the correlation between preclinical studies and clinical trials, new neuroprotective agents and stroke therapies may be more accurately and efficiently identified.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Ischemia
/
Neuroprotective Agents
/
Stroke
/
Ischemic Stroke
Limits:
Animals
/
Humans
Language:
En
Journal:
Transl Stroke Res
Year:
2023
Document type:
Article