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Hyaluronan Oligosaccharides-Coated Paclitaxel-Casein Nanoparticles with Enhanced Stability and Antitumor Activity.
Wang, Man; Zhang, Yahui; Fei, Zuqi; Xie, Dongchao; Zhang, Haihua; Du, Qizhen; Jin, Peng.
Affiliation
  • Wang M; Department of Food Science and Technology, College of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.
  • Zhang Y; Department of Food Science and Technology, College of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.
  • Fei Z; Department of Food Science and Technology, College of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.
  • Xie D; Department of Food Science and Technology, College of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.
  • Zhang H; Department of Food Science and Technology, College of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.
  • Du Q; Department of Food Science and Technology, College of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.
  • Jin P; Department of Food Science and Technology, College of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.
Nutrients ; 14(19)2022 Sep 20.
Article in En | MEDLINE | ID: mdl-36235540
ABSTRACT
This study aims to develop specific-molecular-weight hyaluronic acid oligosaccharides-coated paclitaxel-loaded casein nanoparticles (HA-PT-Cas NPs) via chemical conjugation to increase the stability and antitumor effects. Optimized HA-PT-Cas NPs (HA/casein of 31) were obtained with a mean size of 235.3 nm and entrapment efficiency of 93.1%. HA-PT-Cas exhibited satisfactory stability at 4 °C for 12 days and 37 °C for 3 h; paclitaxel was retained at rates of 81.4% and 64.7%, respectively, significantly higher than those of PT-Cas (only 27.8% at 4 °C after 16 h and 20.3% at 37 °C after 3 h). HA-PT-Cas exhibited high efficiency (61.3%) in inhibiting A375 tumor owing to the enhanced stability of HA oligosaccharides barrier, which was comparable with that of 10 µg/mL cis-platinum (64.9%). Mice experiments showed the 74.6% tumor inhibition of HA-PT-Cas by intravenously administration, significantly higher than that of PT-casein (39.8%). Therefore, this work provides an effective carrier for drug delivery via HA oligomers-coated modification.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paclitaxel / Nanoparticles Limits: Animals Language: En Journal: Nutrients Year: 2022 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paclitaxel / Nanoparticles Limits: Animals Language: En Journal: Nutrients Year: 2022 Document type: Article