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Factors Associated With COVID-19 Non-vaccination in Adolescents Hospitalized Without COVID-19.
Sahni, Leila C; Price, Ashley M; Olson, Samantha M; Newhams, Margaret M; Pannaraj, Pia S; Maddux, Aline B; Halasa, Natasha B; Bline, Katherine E; Cameron, Melissa A; Schwartz, Stephanie P; Walker, Tracie C; Irby, Katherine; Chiotos, Kathleen; Nofziger, Ryan A; Mack, Elizabeth H; Smallcomb, Laura; Bradford, Tamara T; Kamidani, Satoshi; Tarquinio, Keiko M; Cvijanovich, Natalie Z; Schuster, Jennifer E; Bhumbra, Samina S; Levy, Emily R; Hobbs, Charlotte V; Cullimore, Melissa L; Coates, Bria M; Heidemann, Sabrina M; Gertz, Shira J; Kong, Michele; Flori, Heidi R; Staat, Mary A; Zinter, Matt S; Hume, Janet R; Chatani, Brandon M; Gaspers, Mary G; Maamari, Mia; Randolph, Adrienne G; Patel, Manish M; Boom, Julie A.
Affiliation
  • Sahni LC; Department of Pediatrics, Baylor College of Medicine, Immunization Project, Texas Children's Hospital, Houston, Texas, USA.
  • Price AM; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Olson SM; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Newhams MM; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Pannaraj PS; Division of Infectious Diseases, Children's Hospital Los Angeles and Departments of Pediatrics and Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California, USA.
  • Maddux AB; Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.
  • Halasa NB; Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Bline KE; Division of Pediatric Critical Care Medicine, Nationwide Children's Hospital Columbus, Columbus, Ohio, USA.
  • Cameron MA; Division of Pediatric Hospital Medicine, UC San Diego-Rady Children's Hospital, San Diego, California, USA.
  • Schwartz SP; Department of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, North Carolina, USA.
  • Walker TC; Department of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, North Carolina, USA.
  • Irby K; Section of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, Arkansas, USA.
  • Chiotos K; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Nofziger RA; Division of Critical Care Medicine, Department of Pediatrics, Akron Children's Hospital, Akron, Ohio, USA.
  • Mack EH; Division of Pediatric Critical Care Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
  • Smallcomb L; Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA.
  • Bradford TT; Department of Pediatrics, Division of Cardiology, Louisiana State University Health Sciences Center and Children's Hospital of New Orleans, New Orleans, Los Angeles, USA.
  • Kamidani S; The Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and the Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Tarquinio KM; Division of Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Cvijanovich NZ; Division of Critical Care Medicine, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA.
  • Schuster JE; Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
  • Bhumbra SS; The Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Levy ER; Divisions of Pediatric Infectious Diseases and Pediatric Critical Care Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
  • Hobbs CV; Department of Pediatrics, Department of Microbiology, Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Cullimore ML; Division of Pediatric Critical Care, Department of Pediatrics, Children's Hospital and Medical Center, Omaha, Nebraska, USA.
  • Coates BM; Division of Critical Care Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
  • Heidemann SM; Division of Pediatric Critical Care Medicine, Children's Hospital of MI, Central Michigan University, Detroit, Michigan, USA.
  • Gertz SJ; Division of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
  • Kong M; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Flori HR; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Mott Children's Hospital and University of Michigan, Ann Arbor, Michigan, USA.
  • Staat MA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Zinter MS; Department of Pediatrics, Divisions of Critical Care Medicine and Allergy, Immunology, and Bone Marrow Transplant, University of California San Francisco, San Francisco, California, USA.
  • Hume JR; Division of Pediatric Critical Care, University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota, USA.
  • Chatani BM; Division of Pediatric Infectious Diseases, Department of Pediatrics, UHealth/Holtz Children's Hospital, Miami, Florida, USA.
  • Gaspers MG; University of Arizona, Diamond Children's Banner Children's Medical Center, Tucson, Arizona, USA.
  • Maamari M; Department of Pediatrics, Division of Critical Care Medicine, University of Texas Southwestern, Children's Medical Center Dallas, Dallas, Texas, USA.
  • Randolph AG; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Patel MM; Departments of Anaesthesia and Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
  • Boom JA; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Pediatric Infect Dis Soc ; 12(1): 29-35, 2023 Feb 09.
Article in En | MEDLINE | ID: mdl-36309873
ABSTRACT

BACKGROUND:

Pfizer-BioNTech COVID-19 vaccine received emergency use authorization for persons ≥ 16 years in December 2020 and for adolescents 12-15 years in May 2021. Despite the clear benefits and favorable safety profile, vaccine uptake in adolescents has been suboptimal. We sought to assess factors associated with COVID-19 non-vaccination in adolescents 12-18 years of age.

METHODS:

Between June 1, 2021 and April 29, 2022, we assessed factors associated with COVID-19 non-vaccination in hospitalized adolescents ages 12-18 years enrolled in the Overcoming COVID-19 vaccine effectiveness network. Demographic characteristics and clinical information were captured through parent interviews and/or electronic medical record abstraction; COVID-19 vaccination was assessed through documented sources. We assessed associations between receipt of the COVID-19 vaccine and demographic and clinical factors using univariate and multivariable logistic regression and estimated adjusted odds ratios (aOR) for each factor associated with non-vaccination.

RESULTS:

Among 1665 hospitalized adolescents without COVID-19, 56% were unvaccinated. Unvaccinated adolescents were younger (median age 15.1 years vs. 15.4 years, p < .01) and resided in areas with higher social vulnerability index (SVI) scores (median 0.6 vs 0.5, p < .001) than vaccinated adolescents. Residence in the Midwest [aOR 2.60 (95% CI 1.80, 3.79)] or South [aOR 2.49 (95% CI 1.77, 3.54)] US census regions, rarely or never receiving influenza vaccine [aOR 5.31 (95% CI 3.81, 7.47)], and rarely or never taking precautions against COVID-19 [aOR 3.17 (95% CI 1.94, 5.31)] were associated with non-vaccination against COVID-19.

CONCLUSIONS:

Efforts to increase COVID-19 vaccination of adolescents should focus on persons with geographic, socioeconomic, and medical risk factors associated with non-vaccination.
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 / 4_TD Database: MEDLINE Main subject: COVID-19 Type of study: Risk_factors_studies Limits: Adolescent / Child / Humans Language: En Journal: J Pediatric Infect Dis Soc Year: 2023 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 / 4_TD Database: MEDLINE Main subject: COVID-19 Type of study: Risk_factors_studies Limits: Adolescent / Child / Humans Language: En Journal: J Pediatric Infect Dis Soc Year: 2023 Document type: Article