Copper(I)-Catalyzed Three-Component Selenosulfonation of Maleimides with Sulfonyl Hydrazides and Diselenides via Radical Relay.
J Org Chem
; 87(22): 15661-15669, 2022 11 18.
Article
in En
| MEDLINE
| ID: mdl-36317696
ABSTRACT
By employing Cu(CH3CN)4PF6 as the catalyst and tert-butyl hydroperoxide as the oxidant, we realized a three-component radical selenosulfonation of substituted maleimides, sulfonyl hydrazides, and diphenyl diselenides, providing a series of 3,4-selenosulfonylated succinimides in moderate to good yields. This reaction features broad substrate scopes, high functional-group tolerability, and feasibility of gram-scale synthesis, enabling one-step construction of C-SO2 and C-Se bonds under mild reaction conditions. Preliminary mechanistic studies support the free-radical-induced pathway.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Copper
/
Iodine
Language:
En
Journal:
J Org Chem
Year:
2022
Document type:
Article