Household Transmission Dynamics of Seasonal Human Coronaviruses.
J Infect Dis
; 227(9): 1104-1112, 2023 04 26.
Article
in En
| MEDLINE
| ID: mdl-36350773
ABSTRACT
BACKGROUND:
Household transmission studies inform how viruses spread among close contacts, but few characterize household transmission of endemic coronaviruses.METHODS:
We used data collected from 223 households with school-age children participating in weekly disease surveillance over 2 respiratory virus seasons (December 2015 to May 2017), to describe clinical characteristics of endemic human coronaviruses (HCoV-229E, HcoV-HKU1, HcoV-NL63, HcoV-OC43) infections, and community and household transmission probabilities using a chain-binomial model correcting for missing data from untested households.RESULTS:
Among 947 participants in 223 households, we observed 121 infections during the study, most commonly subtype HCoV-OC43. Higher proportions of infected children (<19 years) displayed influenza-like illness symptoms than infected adults (relative risk, 3.0; 95% credible interval [CrI], 1.5-6.9). The estimated weekly household transmission probability was 9% (95% CrI, 6-13) and weekly community acquisition probability was 7% (95% CrI, 5-10). We found no evidence for differences in community or household transmission probabilities by age or symptom status. Simulations suggest that our study was underpowered to detect such differences.CONCLUSIONS:
Our study highlights the need for large household studies to inform household transmission, the challenges in estimating household transmission probabilities from asymptomatic individuals, and implications for controlling endemic CoVs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Tract Infections
/
Viruses
/
Coronavirus Infections
/
Coronavirus 229E, Human
/
Coronavirus OC43, Human
/
Coronavirus NL63, Human
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Adult
/
Child
/
Humans
Language:
En
Journal:
J Infect Dis
Year:
2023
Document type:
Article