Mechanism of LSD1 in oxygen-glucose deprivation/reoxygenation-induced pyroptosis of retinal ganglion cells via the miR-21-5p/NLRP12 axis.

Yu, Xiuling; Niu, Tongtong; Liu, Chi

Yu, Xiuling; Niu, Tongtong; Liu, Chi.

Affiliation

Yu X; Department of Ophthalmology, China Medical University the Fourth People's Hospital of Shenyang, No.20 Huang He Street, Huang Gu District, Shenyang City, 110031, Liaoning Province, China. syyuxiuling@163.com.
Niu T; Department of Ophthalmology, China Medical University the Fourth People's Hospital of Shenyang, No.20 Huang He Street, Huang Gu District, Shenyang City, 110031, Liaoning Province, China.
Liu C; Department of Ophthalmology, China Medical University the Fourth People's Hospital of Shenyang, No.20 Huang He Street, Huang Gu District, Shenyang City, 110031, Liaoning Province, China.

BMC Neurosci ; 23(1): 63, 2022 11 10.

Article in En | MEDLINE | ID: mdl-36357913

Subject(s)

MicroRNAs; Pyroptosis; Mice; Animals; Pyroptosis/physiology; NLR Family, Pyrin Domain-Containing 3 Protein/genetics; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Interleukin-18/metabolism; Interleukin-18/pharmacology; Caspase 1/metabolism; Caspase 1/pharmacology; Glucose; Retinal Ganglion Cells/metabolism; Oxygen; Lysine; Cell Line; MicroRNAs/genetics; Histone Demethylases/pharmacology; RNA, Messenger; Intracellular Signaling Peptides and Proteins/pharmacology

Key words

Epigenetic modification; Histone H3; LSD1; NLRP12; Oxygen-glucose deprivation/reoxygenation; Pyroptosis; Retinal ganglion cells; miR-21-5p

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs / Pyroptosis Limits: Animals Language: En Journal: BMC Neurosci Year: 2022 Document type: Article

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