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Changes in Etiology of Invasive Bacterial Infections in Infants Under 3 Months of Age in Korea, 2006-2020.
Song, Seung Ha; Lee, Hoan Jong; Song, Eun Song; Ahn, Jong Gyun; Park, Su Eun; Lee, Taekjin; Cho, Hye-Kyung; Lee, Jina; Kim, Yae-Jean; Jo, Dae Sun; Kim, Jong-Hyun; Kang, Hyun Mi; Lee, Joon Kee; Kim, Chun Soo; Kim, Dong Hyun; Kim, Hwang Min; Choi, Jae Hong; Eun, Byung Wook; Kim, Nam Hee; Cho, Eun Young; Kim, Yun-Kyung; Oh, Chi Eun; Kim, Kyung-Hyo; Ma, Sang Hyuk; Jung, Hyun Joo; Lee, Kun Song; Kim, Kwang Nam; Lee, Hyunju; Choi, Eun Hwa.
Affiliation
  • Song SH; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
  • Lee HJ; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
  • Song ES; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Ahn JG; Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea.
  • Park SE; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Lee T; Department of Pediatrics, Pusan National University College of Medicine, Yangsan, Korea.
  • Cho HK; Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • Lee J; Department of Pediatrics, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
  • Kim YJ; Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  • Jo DS; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Kim JH; Department of Pediatrics, Jeonbuk National University Medical School, Jeonju, Korea.
  • Kang HM; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • Lee JK; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • Kim CS; Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • Kim DH; Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea.
  • Kim HM; Department of Pediatrics, Inha University College of Medicine, Incheon, Korea.
  • Choi JH; Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • Eun BW; Department of Pediatrics, Jeju National University School of Medicine, Jeju, Korea.
  • Kim NH; Department of Pediatrics, Nowon Eulji University School of Medicine, Eulji University Hospital, Seoul, Korea.
  • Cho EY; Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • Kim YK; Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea.
  • Oh CE; Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea.
  • Kim KH; Department of Pediatrics, Kosin University Gospel Hospital, Busan, Korea.
  • Ma SH; Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea.
  • Jung HJ; Department of Pediatrics, Fatima Hospital, Changwon, Korea.
  • Lee KS; Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • Kim KN; Department of Pediatrics, Dankook University College of Medicine, Cheonan, Korea.
  • Lee H; Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, Korea.
  • Choi EH; Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea.
Pediatr Infect Dis J ; 41(12): 941-946, 2022 12 01.
Article in En | MEDLINE | ID: mdl-36375095
ABSTRACT

OBJECTIVES:

Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea.

METHODS:

A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset disease (LOD) (7-89 days). The temporal trend change in proportion of pathogens was analyzed.

RESULTS:

Among 1545 cases, the median age was 28 days (IQR 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = -0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01).

CONCLUSION:

During 2006-2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Streptococcal Infections / Bacterial Infections Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adult / Humans / Infant Language: En Journal: Pediatr Infect Dis J Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Streptococcal Infections / Bacterial Infections Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adult / Humans / Infant Language: En Journal: Pediatr Infect Dis J Year: 2022 Document type: Article