HIV-associated nephropathy in children: challenges in a resource-limited setting.
Pediatr Nephrol
; 38(8): 2509-2521, 2023 08.
Article
in En
| MEDLINE
| ID: mdl-36472655
ABSTRACT
HIV infection remains one of the leading causes of morbidity and mortality worldwide, especially in children living in resource-limited settings. Although the World Health Organization (WHO) recently recommended antiretroviral therapy (ART) initiation upon diagnosis regardless of the number of CD4, ART access remains limited, especially in children living in sub-Saharan Africa (SSA). HIV-infected children who do not receive appropriate ART are at increased risk of developing HIV-associated nephropathy (HIVAN). Although due to genetic susceptibility, SSA is recognized to be the epicenter of HIVAN, limited information is available regarding the burden of HIVAN in children living in Africa. The present review discusses the information available to date on the prevalence, pathogenesis, risk factors, diagnosis, and management of HIVAN in children, focusing on related challenges in a resource-limited setting.
Key words
Full text:
1
Collection:
01-internacional
Health context:
2_ODS3
Database:
MEDLINE
Main subject:
HIV Infections
/
AIDS-Associated Nephropathy
Type of study:
Risk_factors_studies
Limits:
Child
/
Humans
Country/Region as subject:
Africa
Language:
En
Journal:
Pediatr Nephrol
Year:
2023
Document type:
Article