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Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists.
Prieto-Díaz, Rubén; González-Gómez, Manuel; Fojo-Carballo, Hugo; Azuaje, Jhonny; El Maatougui, Abdelaziz; Majellaro, Maria; Loza, María I; Brea, José; Fernández-Dueñas, Víctor; Paleo, M Rita; Díaz-Holguín, Alejandro; Garcia-Pinel, Beatriz; Mallo-Abreu, Ana; Estévez, Juan C; Andújar-Arias, Antonio; García-Mera, Xerardo; Gomez-Tourino, Iria; Ciruela, Francisco; Salas, Cristian O; Gutiérrez-de-Terán, Hugo; Sotelo, Eddy.
Affiliation
  • Prieto-Díaz R; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • González-Gómez M; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Fojo-Carballo H; Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, 75124Uppsala, Sweden.
  • Azuaje J; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • El Maatougui A; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Majellaro M; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Loza MI; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Brea J; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Fernández-Dueñas V; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Paleo MR; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Díaz-Holguín A; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Garcia-Pinel B; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Mallo-Abreu A; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Estévez JC; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Andújar-Arias A; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • García-Mera X; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Gomez-Tourino I; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Ciruela F; Pharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, 08907L'Hospitalet de Llobregat, Spain.
  • Salas CO; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, 08907L'Hospitalet de Llobregat, Spain.
  • Gutiérrez-de-Terán H; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
  • Sotelo E; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
J Med Chem ; 66(1): 890-912, 2023 01 12.
Article in En | MEDLINE | ID: mdl-36517209
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Halogenation / Purinergic P1 Receptor Antagonists Limits: Animals / Humans Language: En Journal: J Med Chem Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Halogenation / Purinergic P1 Receptor Antagonists Limits: Animals / Humans Language: En Journal: J Med Chem Year: 2023 Document type: Article