Your browser doesn't support javascript.
loading
Epilepsy with anterior temporal encephaloceles: Baseline characteristics, post-surgical outcomes, and comparison to mesial temporal sclerosis.
Samudra, Niyatee; Armour, Eric; Gonzalez, Hernan; Mattingly, Danielle; Haas, Kevin; Singh, Pradumna; Sonmezturk, Hasan; Gallagher, Martin; Crudele, Angela; Nobis, William; Reddy, Shilpa; Jacobs, Monica; Aulino, Joseph M; Bick, Sarah; Morgan, Victoria; Englot, Dario; Abou-Khalil, Bassel.
Affiliation
  • Samudra N; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Armour E; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Gonzalez H; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Mattingly D; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Haas K; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Singh P; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Sonmezturk H; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Gallagher M; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Crudele A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Nobis W; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Reddy S; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Jacobs M; Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Aulino JM; Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Bick S; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Morgan V; Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Englot D; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Abou-Khalil B; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: bassel.abou-khalil@vumc.org.
Epilepsy Behav ; 139: 109061, 2023 02.
Article in En | MEDLINE | ID: mdl-36587487
OBJECTIVE: To review clinical and neuropsychological characteristics and natural history of a series of patients with temporal lobe epilepsy (TLE) and anterior temporal encephaloceles (ATE) and compare them to a similar series of TLE patients with mesial temporal sclerosis (MTS) to identify characteristics suggestive of ATE-related epilepsy. METHODS: Patients with epilepsy and ATE were identified via clinic encounters and consensus epilepsy surgery conference at a Level 4 epilepsy center. The drug-resistant subset of these patients who underwent epilepsy surgery (twenty-two of thirty-five) were compared to age- and laterality-matched patients with MTS. Clinical, neuropsychological, electrophysiologic, and surgical data were abstracted through chart review. RESULTS: In comparison with MTS, ATE patients were more often female, had significantly later onset of epilepsy, and did not have prior febrile seizures. In addition, ATE patients were more likely to have chronic headaches and other historical features consistent with idiopathic intracranial hypertension (IIH). Failure to identify ATE on initial imaging was common. Most patients had limited temporal cortical resections sparing mesial structures. Of the twenty ATE patients who had a long-term postsurgical follow-up, seventeen (85%) had International League Against Epilepsy (ILAE) Class 1 or 2 outcomes. SIGNIFICANCE: A shorter duration of epilepsy, female gender, and lack of history of febrile seizures may suggest ATE as an etiology of refractory TLE in adults. Targeted encephalocele resections can result in seizure freedom, underscoring the importance of encephalocele identification.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures, Febrile / Epilepsy, Temporal Lobe / Hippocampal Sclerosis Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Epilepsy Behav Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures, Febrile / Epilepsy, Temporal Lobe / Hippocampal Sclerosis Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Epilepsy Behav Year: 2023 Document type: Article