<i>In Vivo</i> Mechanism of Action of Sodium Caprate for Improving the Intestinal Absorption of a GLP1/GIP Coagonist Peptide.

Tran, Huyen; Aihara, Eitaro; Mohammed, Faiz Ahmad; Qu, Hongchang; Riley, Andrew; Su, Yuan; Lai, Xianyin; Huang, Siyuan; Aburub, Aktham; Chen, Jack Jia Hua; Vitale, Olivia Hope; Lao, Yanbin; Estwick, Selina; Qi, Zhonghua; ElSayed, Mohamed E H

In Vivo Mechanism of Action of Sodium Caprate for Improving the Intestinal Absorption of a GLP1/GIP Coagonist Peptide.

Tran, Huyen; Aihara, Eitaro; Mohammed, Faiz Ahmad; Qu, Hongchang; Riley, Andrew; Su, Yuan; Lai, Xianyin; Huang, Siyuan; Aburub, Aktham; Chen, Jack Jia Hua; Vitale, Olivia Hope; Lao, Yanbin; Estwick, Selina; Qi, Zhonghua; ElSayed, Mohamed E H.

Mol Pharm ; 20(2): 929-941, 2023 02 06.

Article in En | MEDLINE | ID: mdl-36592951

Subject(s)

Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Swine; Rats; Animals; Gastric Inhibitory Polypeptide/metabolism; Gastric Inhibitory Polypeptide/pharmacology; Glucagon-Like Peptide 1/metabolism; Swine, Miniature/metabolism; Decanoic Acids/pharmacology; Intestinal Absorption; Intestinal Mucosa/metabolism; Peptides/metabolism

Key words

intestinal absorption; intestinal tissue distribution; oral peptide delivery; physicochemical properties; sodium caprate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastric Inhibitory Polypeptide / Glucagon-Like Peptide 1 Limits: Animals Language: En Journal: Mol Pharm Year: 2023 Document type: Article

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