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Lactiplantibacillus plantarum BW2013 protects mucosal integrity and modulates gut microbiota of mice with colitis.
Niu, Xiaohui; Li, Qian; Luan, Na; Liu, Jia; Zhang, Michael; An, Jun; Li, Zuming; Bai, Zhihui; Xia, Ran; Wu, Zhichao.
Affiliation
  • Niu X; Department of Food Science and Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
  • Li Q; Department of Food Science and Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
  • Luan N; Department of Food Science and Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
  • Liu J; Internal Trade Food Science and Technology (Beijing) Co., Ltd, Beijing 102209, China.
  • Zhang M; Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
  • An J; Department of Food Science and Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
  • Li Z; Zhejiang Yangshengtang Natural Medicine Research Institute Co., Ltd, Hangzhou 310024, China.
  • Bai Z; Department of Food Science and Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
  • Xia R; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
  • Wu Z; Internal Trade Food Science and Technology (Beijing) Co., Ltd, Beijing 102209, China.
Can J Microbiol ; 69(4): 158-169, 2023 Apr 01.
Article in En | MEDLINE | ID: mdl-36669152
ABSTRACT
This study explored the effects of Lactiplantibacillus plantarum (previously Lactobacillus plantarum) BW2013 on mucosal integrity and gut microbiota of mice with dextran sulfate sodium (DSS)-induced colitis. The results show that the clinical symptoms in DSS-modelled ulcerative colitis (UC) were improved by L. plantarum BW2013 via decreasing disease activity index scores and suppressing inflammatory cell infiltration. Furthermore, L. plantarum BW2013 decreased the levels of diamine oxidase activity, myeloperoxidase, and D-lactic acid. The mRNA expression of ZO-1, occludin, and claudin-1 was upregulated by L. plantarum BW2013, which also increased IL-10 and reduced TNF-α, IL-1ß, and IL-6 in the colon. 16S rDNA sequencing showed that L. plantarum BW2013 enhanced α-diversity. L. plantarum BW2013 upregulated significantly the abundance of unidentfied Lachnospiraceae, Lactococcus, Rikenella, Lactobacillus, and Odoribacter, which had an inhibitory effect on inflammation and a protective effect on the integrity of the mucosa. These results demonstrate that L. plantarum BW2013 alleviates DSS-modelled UC by protecting mucosal integrity and ameliorating the composition of gut microbiota.
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Colitis, Ulcerative / Colitis / Gastrointestinal Microbiome Type of study: Prognostic_studies Limits: Animals Language: En Journal: Can J Microbiol Year: 2023 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Colitis, Ulcerative / Colitis / Gastrointestinal Microbiome Type of study: Prognostic_studies Limits: Animals Language: En Journal: Can J Microbiol Year: 2023 Document type: Article