Successful second conversion surgery after trastuzumab deruxtecan for recurrent HER2-positive gastric cancer.
Clin J Gastroenterol
; 16(3): 330-335, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-36708503
ABSTRACT
A 65-year-old woman with HER2-positive gastric cancer with multiple liver metastases underwent first conversion surgery of gastrectomy with D2 lymph nodes dissection and three liver metastases after combination therapy with capecitabine, cisplatin, and trastuzumab. Two years later, she experienced multiple liver metastases that were refractory to combination therapy with paclitaxel albumin-bound nanoparticles and ramucirumab. She participated in the DESTINY-Gastric01 trial and received tri-weekly trastuzumab deruxtecan as third-line treatment for 26 cycles. The recurrent lesions markedly shrank, and this effect continued for 19 months. We then performed partial hepatectomy for the one remaining lesion. No adjuvant chemotherapy was given, and she remains alive without recurrence 18 months after the second conversion surgery. Trastuzumab deruxtecan may generate a notable tumor response and subsequent conversion surgery could be a treatment option for HER2-positive stage IV gastric cancer.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Liver Neoplasms
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
Clin J Gastroenterol
Year:
2023
Document type:
Article