Design and cytotoxic evaluation via apoptotic and antiproliferative activity for novel 11(4-aminophenylamino)neocryptolepine on hepatocellular and colorectal cancer cells.

Nagy, Esraa Tariq; Ahmed, Abdullah A S; Elmongy, Elshaymaa I; El-Gendy, Saad M; Elmadbouh, Ibrahim; El Sayed, Ibrahim El Tantawy; Abd Eldaim, Mabrouk Attia; El-Gokha, Ahmed A

Nagy, Esraa Tariq; Ahmed, Abdullah A S; Elmongy, Elshaymaa I; El-Gendy, Saad M; Elmadbouh, Ibrahim; El Sayed, Ibrahim El Tantawy; Abd Eldaim, Mabrouk Attia; El-Gokha, Ahmed A.

Affiliation

Nagy ET; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, 32511, Egypt.
Ahmed AAS; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, 32511, Egypt.
Elmongy EI; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, 84428, Saudi Arabia.
El-Gendy SM; Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt.
Elmadbouh I; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
El Sayed IET; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, 32511, Egypt.
Abd Eldaim MA; Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Menoufia University, Sheben Elkom, 32511, Menoufia, Egypt. mabroukattia@vet.menofia.edu.eg.
El-Gokha AA; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, 32511, Egypt.

Apoptosis ; 28(3-4): 653-668, 2023 04.

Article in En | MEDLINE | ID: mdl-36719468

Subject(s)

Antineoplastic Agents; Carcinoma, Hepatocellular; Colorectal Neoplasms; Liver Neoplasms; Humans; Caspase 3/metabolism; Carcinoma, Hepatocellular/drug therapy; Molecular Docking Simulation; Liver Neoplasms/drug therapy; Liver Neoplasms/genetics; Apoptosis; Antineoplastic Agents/therapeutic use; HCT116 Cells; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/genetics; Cell Proliferation

Key words

APAN; Caspase 3; Ki67; P53; PCNA; VEGF

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Colorectal Neoplasms / Carcinoma, Hepatocellular / Liver Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Apoptosis Year: 2023 Document type: Article

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