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Osteolysis in Systemic Sclerosis: A Scoping Review.
Guerra, Miguel Gomes; Rodrigues, Mariana; Águeda, Ana; Rodrigues, Joana; Marona, José; Violante, António; Oliveira, Margarida.
Affiliation
  • Guerra MG; M.G. Guerra, MD, A. Águeda, MD, J. Rodrigues, MD, J. Marona, MD, A. Violante, MD, Rheumatology Department, Centro Hospitalar Universitário Cova da Beira; mlgomesg@gmail.com.
  • Rodrigues M; M. Rodrigues, MD, Faculty of Health Sciences, Universidade da Beira Interior.
  • Águeda A; M.G. Guerra, MD, A. Águeda, MD, J. Rodrigues, MD, J. Marona, MD, A. Violante, MD, Rheumatology Department, Centro Hospitalar Universitário Cova da Beira.
  • Rodrigues J; M.G. Guerra, MD, A. Águeda, MD, J. Rodrigues, MD, J. Marona, MD, A. Violante, MD, Rheumatology Department, Centro Hospitalar Universitário Cova da Beira.
  • Marona J; M.G. Guerra, MD, A. Águeda, MD, J. Rodrigues, MD, J. Marona, MD, A. Violante, MD, Rheumatology Department, Centro Hospitalar Universitário Cova da Beira.
  • Violante A; M.G. Guerra, MD, A. Águeda, MD, J. Rodrigues, MD, J. Marona, MD, A. Violante, MD, Rheumatology Department, Centro Hospitalar Universitário Cova da Beira.
  • Oliveira M; M. Oliveira, MD, Rheumatology Department, Centro Hospitalar Universitário Cova da Beira, and Faculty of Health Sciences, Universidade da Beira Interior, Covilhã, Portugal.
J Rheumatol ; 50(7): 863-872, 2023 07.
Article in En | MEDLINE | ID: mdl-36725053
OBJECTIVE: To perform a scoping review focusing on osteolysis in systemic sclerosis (SSc). METHODS: This review was performed in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) recommendations. RESULTS: From a total of 351 results, 29 articles were included for the final analysis. The publications included proved to be heterogeneous regarding the population and inclusion criteria. The lack of a standardized method of detection of osteolysis further enhanced these inequalities. Most studies reported location/prevalence of osteolysis and associations with other manifestations, with only a minority focusing on topics like predictors of osteolysis and its prognostic value. None of the authors addressed treatment approach. The most frequently analyzed and prevalent location was acro-osteolysis (AO). Diffuse cutaneous subtype and anti-topoisomerase I antibody correlated positively with AO. Disease duration, calcinosis, and digital ischemia were the features more frequently associated with AO, but only the last 2 predicted AO. Ultrasound showed high sensitivity for detection of AO. CONCLUSION: Despite the effect that osteolysis has on patients with SSc, there is a significant lack of studies on this area. Notably, there are no studies that we know of focused on treatment. Also, there is a lack of longitudinal studies that would allow a reliable assessment of its prognostic value and predictors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteolysis / Scleroderma, Systemic / Acro-Osteolysis Type of study: Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: J Rheumatol Year: 2023 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteolysis / Scleroderma, Systemic / Acro-Osteolysis Type of study: Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: J Rheumatol Year: 2023 Document type: Article