Neutron brachytherapy in the modern era: Indications and evidence.
Cancer Radiother
; 27(2): 170-177, 2023 Apr.
Article
in En
| MEDLINE
| ID: mdl-36759242
ABSTRACT
Hadrontherapy is a form of radiation therapy (RT) that relies on heavy particles, such as proton, heavy ions, or neutrons, to enhance anti-tumoral efficacy based on their specific dosimetric and radio-biological properties. Neutrons are characterized by specific radiobiological properties that might deserve greater consideration, including the high linear energy transfer and the low oxygen enhancement ratio. Neutron brachytherapy, relying on interstitial or intracavitary neutron sources, has been developed since the 1950s using Californium-252 (252Cf) as a mixed emitter of fission fast neutrons and γ-photos. However, the place of NBT in the era of modern radiation therapy is yet to be precisely defined. In this systematic review, we aim to provide an up-to-date analysis of current experience and clinical evidence of NBT in the XXI th century, by answering the following clinical questions How is NBT currently delivered? What are the current efficacy data and tolerance profiles of NBT?
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brachytherapy
/
Neoplasms
Type of study:
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Cancer Radiother
Year:
2023
Document type:
Article