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NKp46-specific single domain antibodies enable facile engineering of various potent NK cell engager formats.
Lipinski, Britta; Arras, Paul; Pekar, Lukas; Klewinghaus, Daniel; Boje, Ammelie Svea; Krah, Simon; Zimmermann, Jasmin; Klausz, Katja; Peipp, Matthias; Siegmund, Vanessa; Evers, Andreas; Zielonka, Stefan.
Affiliation
  • Lipinski B; Protein Engineering and Antibody Technologies, Merck Healthcare KGaA, Darmstadt, Germany.
  • Arras P; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany.
  • Pekar L; Protein Engineering and Antibody Technologies, Merck Healthcare KGaA, Darmstadt, Germany.
  • Klewinghaus D; Protein Engineering and Antibody Technologies, Merck Healthcare KGaA, Darmstadt, Germany.
  • Boje AS; Protein Engineering and Antibody Technologies, Merck Healthcare KGaA, Darmstadt, Germany.
  • Krah S; Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany.
  • Zimmermann J; Protein Engineering and Antibody Technologies, Merck Healthcare KGaA, Darmstadt, Germany.
  • Klausz K; Protein Engineering and Antibody Technologies, Merck Healthcare KGaA, Darmstadt, Germany.
  • Peipp M; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany.
  • Siegmund V; Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany.
  • Evers A; Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany.
  • Zielonka S; Protein and Cell Sciences, Merck Healthcare KGaA, Darmstadt, Germany.
Protein Sci ; 32(3): e4593, 2023 03.
Article in En | MEDLINE | ID: mdl-36775946
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Bispecific / Single-Domain Antibodies / Neoplasms Limits: Humans Language: En Journal: Protein Sci Year: 2023 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Bispecific / Single-Domain Antibodies / Neoplasms Limits: Humans Language: En Journal: Protein Sci Year: 2023 Document type: Article